Papers and Manuscripts

IMML Manuscripts

Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour-bearing mice. Brown JL, Rosa-Caldwell ME, Lee DE, Blackwell TA, Brown LA, Perry RA, Haynie WS, Hardee JP, Carson JA, Wiggs MP, Washington TA, Greene NP. J Cachexia Sarcopenia Muscle. 2017 Dec;8(6):926-938. doi: 10.1002/jcsm.12232.

Cancer cachexia-induced muscle atrophy: evidence for alterations in microRNAs important for muscle size. Lee DE, Brown JL, Rosa-Caldwell ME, Blackwell TA, Perry RA Jr, Brown LA, Khatri B, Seo D, Bottje WG, Washington TA, Wiggs MP, Kong BW, Greene NP. Physiol Genomics. 2017 May 1;49(5):253-260. doi: 10.1152/physiolgenomics.00006.2017.

Autophagy activation, not peroxisome proliferator-activated receptor γ coactivator 1α, may mediate exercise-induced improvements in glucose handling during diet-induced obesity. Rosa-Caldwell ME, Brown JL, Lee DE, Blackwell TA, Turner KW, Brown LA, Perry RA, Haynie WS, Washington TA, Greene NP. Exp Physiol. 2017 Sep 1;102(9):1194-1207. doi: 10.1113/EP086406.

PGC-1α4 gene expression is suppressed by the IL-6-MEK-ERK 1/2 MAPK signalling axis and altered by resistance exercise, obesity and muscle injury. Brown JL, Rosa-Caldwell ME, Lee DE, Brown LA, Perry RA, Shimkus KL, Blackwell TA, Fluckey JD, Carson JA, Dridi S, Washington TA, Greene NP.Acta Physiol (Oxf). 2017 Jun;220(2):275-288. doi: 10.1111/apha.12826.

Moderate physical activity promotes basal hepatic autophagy in diet-induced obese mice. Rosa-Caldwell ME, Lee DE, Brown JL, Brown LA, Perry RA Jr, Greene ES, Carvallo Chaigneau FR, Washington TA, Greene NP. Appl Physiol Nutr Metab. 2017 Feb;42(2):148-156. doi: 10.1139/apnm-2016-0280.

Skeletal muscle insulin resistance as a precursor to Diabetes: Beyond glucoregulation.Greene NP, Brown JL, Rosa-Caldwell ME, Lee DE, Blackwell TA, Washington TA. Curr Diabetes Rev. 2016 Nov 22. 

Translational machinery of mitochondrial mRNA is promoted by physical activity in Western diet-induced obese mice. Lee DE, Brown JL, Rosa ME, Brown LA, Perry RA, Washington TA, Greene NP. Acta Physiol (Oxf). 2016 Nov;218(3):167-177. doi: 10.1111/apha.12687.

microRNA-16 Is Downregulated During Insulin Resistance and Controls Skeletal Muscle Protein Accretion. Lee DE, Brown JL, Rosa ME, Brown LA, Perry RA Jr, Wiggs MP, Nilsson MI, Crouse SF, Fluckey JD, Washington TA, Greene NP. J Cell Biochem. 2016 Aug;117(8):1775-87. doi: 10.1002/jcb.25476.

Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice. Greene NP, Lee DE, Brown JL, Rosa ME, Brown LA, Perry RA, Henry JN, Washington TA. Physiol Rep. 2015 Jul;3(7). pii: e12470. doi: 10.14814/phy2.12470.

Impaired exercise-induced mitochondrial biogenesis in the obese Zucker rat, despite PGC-1α induction, is due to compromised mitochondrial translation elongation. Greene NP, Nilsson MI, Washington TA, Lee DE, Brown LA, Papineau AM, Shimkus KL, Greene ES, Crouse SF, Fluckey JD. Am J Physiol Endocrinol Metab. 2014 Mar 1;306(5):E503-11. doi: 10.1152/ajpendo.00671.2013.

Collaboration papers

Optical imaging of radiation-induced metabolic changes in radiation-sensitive and resistant cancer cells. Alhallak K, Jenkins SV, Lee DE, Greene NP, Quinn KP, Griffin RJ, Dings RPM, Rajaram N. J Biomed Opt. 2017 Jun 1;22(6):60502. doi: 10.1117/1.JBO.22.6.060502.

The Akt/mTOR pathway: Data comparing young and aged mice with leucine supplementation at the onset of skeletal muscle regeneration. Perry RA Jr, Brown LA, Lee DE, Brown JL, Baum JI, Greene NP, Washington TA. Data Brief. 2016 Aug 11;8:1426-32. doi: 10.1016/j.dib.2016.08.013.

Differential effects of leucine supplementation in young and aged mice at the onset of skeletal muscle regeneration Perry RA Jr, Brown LA, Lee DE, Brown JL, Baum JI, Greene NP, Washington TA. Mech Ageing Dev. 2016 Jul;157:7-16. doi: 10.1016/j.mad.2016.05.007.